RESEARCH FUNDING Funded Projects


Projects Funded in 2016-17

Alberta Alzheimer Research Program

(Partnership with the Alzheimer Society of Alberta and Northwest Territories)

 

Holger Wille

Structural characterization of paired helical filaments from different Alzheimer's disease phenotypes by cryo electron microscopy

 

Satyabrata Kar

Lysosomal leakage and acidic PLGA nanoparticles: potential implications in Alzheimer’s disease pathology

 

Howard Young

Atomic resolution structures of beta-amyloid intermediates

 

Majid Mohajerani

Probing the impact of noradrenergic circuit and its role in resetting excitation/inhibition balance in Alzheimer's disease

 

Explorations Program

Stefanie Czub

Transmissibility and characterization of prion protein aggregates in cattle IC challenged with a novel prion protein disorder

 

Stefanie Czub

The role of microglia in preclinical and clinical, classical BSE – a combined immunohistochemical and molecular approach

 

Peter Stys

Probing the central nervous system amylome: advanced quantitative fluorescence spectroscopy in “prion-like” neurodegenerations

 

Michael Woodside

Oligomerisation inhibitors for α-synuclein screened by an integrated computational/experimental platform

 

David Westaway

Prion disease attenuation by designed mobile genetic elements

 

Andriy Kovalenko

Preclinical animal studies of new drug candidates targeting prion-like propagation of pathological misfolding of SOD1 enzyme in ALS

 

Sabine Gilch

Mobilizing neuronal cholesterol transport: a new strategy to treat prion diseases

 

Research Team Program

Holger Wille

Harnessing a novel Aβ-binding compound for Alzheimer disease research and theranostics

 

Holger Wille

Comparing the structures of natural and engineered prions

 

Peter Stys

Multiple sclerosis as a primary protein misfolding disorder

 

Debbie McKenzie

Natural Resources and the Environment: Sector Challenges - Genomic Solutions

(Funding Partnership with Genome Alberta)

 

Specified Risk Materials (SRM) Program

(Funding Partnership with Alberta Agriculture and Forestry)

 

David Bressler

Development of a cheap and renewable binder for torrefied wood pellets

 

David Bressler

Utilization of specified risk materials hydrolysates and their derivatives as surfactants in oil sands tailings management

 

Tim McAllister

Characterizing the inactivation of BSE in field-scale compost piles as an alternative method for disposal of specified risk materials

 

Alberta Neuroscience Program

Robert Sutherland

Imaging spread of pathogenic effects of amyloidß seeding

 

Projects Funded in 2015-16

Alberta Alzheimer Research Program

(Partnership with the Alzheimer Society of Alberta and Northwest Territories)

 

Elena Posse de Chaves

Protein Prenylation and Autophagy in Alzheimer's Disease

 

Satyabrata Kar

Role of Astrocyte-derived exosomes in Alzheimer's disease pathology

 

Jack Jhamandas

Novel therapeutics for Alzheimer’s disease: Amylin receptor based compounds

 

Amir Sanati-Nezhad

Blood-Brain-Barrier on chip to investigate the cross-talk of blood vessel and brain tissue with the application in Alzheimer Disease (AD) treatment

 

Valerie Sim

Detecting transmissible particles in Alzheimer's disease

 

Andriy Kovalenko

Lipid-mediated effects implicated in formation and pathological action of Aβ oligomers in Alzheimer’s disease

 

Janice Braun

Molecular Neuroprotection: Evaluation of the Role of Extracellular Chaperones and Exosomes In the Clearance of Amyloid β

 

Open Program

Hermann Schätzl

Final proof for presence or absence of prion infectivity and conversion activity in incubating macaques inoculated orally with CWD prions

 

Explorations Program

David Westaway

Development of methods for assaying Tau prion strains

 

Michael James

Structural and biophysical characterization of the protective prion protein variant V127

 

Ted Allison

Restoring prion mutants’ synaptic physiology and learning/memory: Engineering zebrafish to enable in vivo drug screens

 

Holger Wille

Structure-based, rational design of vaccine candidates targeting Chronic Wasting Disease

(funding partnership with ALMA)

 

Michael Woodside

Single-molecule studies of factors protecting against PrP misfolding

(funding partnership with ALMA)

 

Michael Woodside

Probing prion-like structural conversion in SOD1 at the single-molecule level

 

Michael Overduin

Prion-Lipid Analysis using Styrene Maleic Acid Nanoparticles (PLASMAN)

 

Valerie Sim

Feasibility Study - Cervid prion polymorphism effects on aggregation and seeding: implications for cross-species transmission

(funding partnership with ALMA)

 

Debbie McKenzie

Atypical transmission of CWD to tgbov mice

(funding partnership with ALMA)

 

Hermann Schätzl

Validating and improving a lead vaccine against CWD

(funding partnership with ALMA)

 

Stefanie Czub

Experimental Transmission of H- and L-type BSE to Susceptible Sheep

(funding partnership with ALMA)

 

Stefanie Czub

Finalizing a Transmission Study of Chronic Wasting Disease (CWD) in Non-Human Primates

(funding partnership with ALMA)

 

ALMA Research & Development Program

(Partnership with the Alberta Livestock and Meat Agency)

David Bressler

Design and Preparation of Biodegradable Tackifiers Incorporating Animal Waste Protein

 

Laboratory Support

David Westaway & Hermann Schätzl

Support of biological testing for prions and toxic misfolded proteins at the University of Alberta and University of Calgary

 

 

Projects Funded in 2014-2015

Alberta Alzheimer Research Program

(Partnership with the Alzheimer Society of Alberta and Northwest Territories)

 

Sabine Gilch

Targeting Ab oligomer-PrPC interaction using peptide aptamers: a novel approaches for treatment of Alzheimer’s disease

 

Satyabrata Kar

Role of astrocytes in the generation and clearance of beta-amyloid peptides: potential implications in Alzheimer's disease pathology

 

Andriy Kovalenko

Pathological aggregation of Abeta peptides in intra- and extracellular environments: Pathways and implications for therapeutics of Alzheimer's disease

 

Majid Mohajerani

A rodent model of the sporadic version of Alzheimer’s disease: Interactions between mini-strokes, betaamyloid and acetylcholine

 

Shigeki Tsutsui

Detection of early Alzheimer’s disease from blood using novel microspectroscopy

 

Canadian Consortium on Neurodegeneration of Aging

Andriy Kovalenko

Predictive description of misfolding and aggregation of proteins implicated in neurodegeneration (funding partnership with a national consortium)  

 

Research Team Program

Evelyn Merrill

Experimental harvest for CSO control in wild cervids (funding partnership with the Alberta Livestock and Meat Agency)  

 

 

Projects Funded in 2013-14
 

Alberta Alzheimer Research Program

(Partnership with the Alzheimer Society of Alberta and Northwest Territories)

 

Jack Jhamandas

Glycolytic modulation of amyloid-astrocyte interactions: implications for Alzheimer’s disease pathogenesis

 

APRI/ALMA Targeted Areas Program

(Partnership with the Alberta Livestock and Meat Agency)

 

Judd Aiken

Environmental chronic wasting disease infectivity

 

Tiejun Gao

Exploring the nutrient value of specified risk materials from thermophilic anaerobic digestion

 

Sabine Gilch

Defining a relationship between biochemical properties of chronic wasting disease prions and prion shedding

 

David Westaway

Biological destruction of prion proteins

 

David Wishart

Developing a vaccine for chronic wasting disease using synthetic, stabilized PrP oligomers

 

Research Team Program

Andriy Kovalenko

Targeting prion-like propagated misfolding of SOD1 for ALS immunotherapy   

 

Holger Wille

Human prions – distinguishing sporadic from familial forms via structure and function

 

Explorations Program

Stefanie Czub

Discrimination of classical and atypical BSE by a distinct PrPSc profile

(funding partnership with ALMA)

 

Stefanie Czub

Oral challenge of classical and atypical BSE to determine transmissibility, age-related susceptibility and agent distribution

(funding partnership with ALMA)

 

Sabine Gilch

Peptide aptamers as therapeutic and analytic tools in prion research    

 

Sabine Gilch

Prion-host cell interaction: importance of prion interference with host cell cholesterol metabolism for persistent prion propagation

 

Michael James

Structure-guided design and biological validation of PrPC stabilization by small compounds using a novel multi-site targeting approach

 

Debbie McKenzie

Cell tropism of prion strains

 

Debbie McKenzie

Determining the diversity of CWD agents

 

Brenda Parlee

Tracking changes in wildlife health – traditional knowledge and Aboriginal peoples

 

Hermann Schätzl

A new anti-prion strategy: modulation of Prnp transcriptional activity

(funding partnership with ALMA)

 

Hermann Schätzl

Between propagation and clearance: the dual role of autophagy in prion infection

          

Hermann Schätzl

Limiting zoonotic potential and spread of chronic wasting disease by wild-life vaccination

 

Valerie Sim

Prion disease therapies trial

(funding partnership with ALMA

 


 

Projects Funded in 2012-13
 

Alberta Alzheimer Research Program

(Partnership with the Alzheimer Society of Alberta and Northwest Territories)

 

Ted Allison

(Young Investigator Award)

Zebrafish models of Alzheimer’s disease

 

Janice Braun

Unravelling the mechanisms of neuroprotection: the link between synaptic loss and lysosome function

 

Satyabrata Kar

Cathepsin D and neuronal vulnerability potential implications in Alzheimer’s disease pathology

 

Roger Thompson

A novel model for sporadic Alzheimer’s disease induced by stroke

 

Shigeki Tsutsui

Detection of Alzheimer’s disease from blood using fluorescence spectroscopy

 

Research Team Program

 

Judd Aiken

Antemortem biomarkers of prion disease

 

Stefanie Czub

Finalizing a risk assessment of chronic wasting disease transmission to humans using non-human primates

(funding partnership with ALMA)

 

Holger Wille

A hybrid approach towards the structure of BSE prions

 

Explorations Program

Janice Braun

New approaches to understanding and preventing neurodegenerative diseases

 

Andriy Kovalenko

Immunological lead towards characterization of toxic oligomers for therapeutic targeting in neurodegenerative diseases

 

Hermann Schätzl

Modulation of protein quality control pathways as a novel intervention strategy in prion diseases

 

Maria Stepanova

Discovering molecular origins of protein misfolding diseases

 

Peter Stys

Role of NDMA receptors in Alzheimer’s disease pathology – a complex interaction with Tau and cellular prion protein

 

Holger Wille

Myotube cultures as a prion source for structural investigations

 

David Wishart

Glycolipids in prion conversion and propagation: mechanisms and models

 

Michael Woodside

Mapping the misfolding pathways of SOD1 directly using single-molecule force spectroscopy

 

Michael Woodside

Probing mechanism for conversion of individual PrP molecules

 


 

Projects Funded in 2011-12
 

Alberta Prion Research Institute/PrioNet Canada Co-Funding

 

Ellen Goddard

Development of an integrated risk management framework for chronic wasting disease

 

Debbie McKenzie

Chronic wasting disease strains

 

Targeted Areas

 

Scott Napper

Testing of chronic wasting disease-specific epitopes for immunogenicity and protection

 

APRI-ALMA Co-Funding

(partnership with the Alberta Livestock and Meat Agency)

 

Michael James

Structural pathobiological and biophysical characterization of cervid prion proteins: towards the development of anti-prion therapeutics for CWD

 

Tim McAllister

Investigation on the potential uptake of pathogenic prion protein by plants grown on prion-contaminated soil

 

Debbie McKenzie

Susceptibility of cattle to CWD prion isolates

 

Holger Wille

Analyzing the structure of CWD prions by cryo electron microscopy

 

David Wishart

Developing a vaccine for CWD using attenuated PrP oligomers